Researchers from the University of Bologna (UNIBO) have published a new peer-reviewed article describing the successful industrial-scale chemical synthesis of gold nanorods (GNRs). The study demonstrates the scale-up of GNR production from laboratory volumes to batches as large as 30 litres, marking a significant step towards real-world manufacturing.
From laboratory research to scalable production
Gold nanorods are of particular interest for biomedical applications due to their unique interaction with light, which makes them suitable for advanced imaging and therapeutic approaches. However, producing these materials in large quantities while maintaining consistent quality has remained a major challenge. PHIRE team demonstrated that careful optimisation of the synthesis process enables the reproducible production of gold nanorods at larger volumes far beyond than previously reported. This achievement represents an important milestone in making such nanomaterials available for real-world biomedical applications.
The study highlights that tight control over key aspects of the synthesis process is essential to preserve the optical properties of gold nanorods during scale-up. By controlling these key parameters, the authors show that consistent material quality can be maintained at larger production volumes.
Supporting translation towards real-world use
This study underscores the importance of integrating materials science, process engineering and biomedical requirements when developing nanomaterials for clinical use. By addressing scalability and reproducibility early in the development process, the study helps reduce barriers to translation and supports the future integration of advanced nanomaterials into imaging and therapeutic technologies.
Beyond the experimental results, the study establishes a robust, industrially relevant production route for gold nanorods, defining key quality attributes and process understanding needed for future Good Manufacturing Practice (GMP) production. This publication strengthens the scientific and translational foundation of the PHIRE project, supporting the development of scalable and reproducible nanomaterials for advanced imaging and theranostic applications.
Read more here: Industrial-scale chemical synthesis of gold nanorods: process optimization and 30 L scale-up toward GMP manufacturing – ScienceDirect
